This paper summarizes the approaches to and the implications of bottom-up infrastructure modeling in the framework of the EMF28 model comparison "Europe 2050: The Effects of Technology Choices on EU Climate Policy". It includes models covering all the sectors currently under scrutiny by the European Infrastructure Priorities: Electricity, natural gas, and CO2. Results suggest that some infrastructure enhancement is required to achieve the decarbonization, and that the network development needs can be attained in a reasonable timeframe. In the electricity sector, additional cross-border interconnection is required, but generation and the development of low-cost renewables is a more challenging task. For natural gas, the falling total consumption could be satisfied by the current infrastructure in place, and even in a high-gas scenario the infrastructure implications remain manageable. Model results on the future role of Carbon Capture, Transport, and Sequestration (CCTS) vary, and suggest that most of the transportation infrastructure might be required in and around the North Sea.