Publikationen des Projekts: Berliner Altersstudie II (BASE-II): Health and Cognitive Functioning across the Lifespan

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Gender Score Development in the Berlin Aging Study II: A Retrospective Approach

In addition to biological sex, gender, defined as the sociocultural dimension of being a woman or a man, plays acentral role in health. However, there are so far few approaches to quantify gender in a retrospective manner inexisting study datasets. We therefore aimed to develop a methodology that can be retrospectively applied to assessgender in existing cohorts. We used baseline data from the Berlin ...

In: Biology of Sex Differences 12 (2021), 15, 10 S. | Ahmad Tauseef Nauman, Hassan Behlouli, Nicholas Alexander, Friederike Kendel, Johanna Drewelies, Konstantinos Mantantzis, Nora Berger, Gert G. Wagner, Denis Gerstorf, Ilja Demuth, Louise Pilote, Vera Regitz-Zagrosek
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Tropospheric Ozone and Skin Aging: Results from Two German Cohort Studies

During the last two decades, it has been well established that a short-term exposure to ozone (O3) elicits an oxidative stress response in human and mouse skin, which leads to aberrant transcriptional expression of genes consistent with increased skin aging. Whether a long-term exposure to ambient O3 is associated with any skin aging traits, has remained unclear. We addressed this question in two elderly ...

In: Environment International 124 (2019), S. 139-144 | Kateryna B. Fuks, Anke Hüls, Dorothea Sugiri, Hicran Altug, Andrea Vierkötter, Michael J. Abramson, Jan Goebel, Gert G. Wagner, Ilja Demuth, Jean Krutmann, Tamara Schikowskia
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Personalized Feedback in Web Surveys: Does it Affect Respondents' Motivation and Data Quality?

Web surveys technically allow providing feedback to the respondents based on their previous responses. This personalized feedback may increase respondents’ motivation and possibly the accuracy of responses. While past studies mainly concentrate on the effects of providing study results on future response rates, thus far survey research lacks theoretical and empirical contributions on the effects of ...

In: Social Science Computer Review 36 (2018), 6, S. 744-755 | Simon Kühne, Martin Kroh
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Historical Trends in Modifiable Indicators of Cardiovascular Health and Self-Rated Health among Older Adults: Cohort Differences over 20 Years between the Berlin Aging Study (Base) and the Berlin Aging Study II (Base-II)

BackgroundThe last decades have seen great advances in the understanding, treatment, and prevention of cardiovascular disease (CVD). Although mortality rates due to CVD have declined significantly in the last decades, the burden of CVD is still high, particularly in older adults. This raises the question whether contemporary populations of older adults are experiencing better or worse objective as ...

In: PloS one 13 (2018), 1, e0191699 | Maximilian König, Johanna Drewelies, Kristina Norman, Dominik Spira, Nikolaus Buchmann, Gizem Hülür, Peter Eibich, Gert G. Wagner, Ulman Lindenberger, Elisabeth Steinhagen-Thiessen, Denis Gerstorf, Ilja Demuth
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Genome-Wide Association Study Identifies 74 Loci Associated with Educational Attainment

Educational attainment is strongly influenced by social and other environmental factors, but genetic factors are estimated to account for at least 20% of the variation across individuals1. Here we report the results of a genome-wide association study (GWAS) for educational attainment that extends our earlier discovery sample1, 2 of 101,069 individuals to 293,723 individuals, and a replication study ...

In: Nature 533 (2016), 7604, S. 539-542 | Aysu Okbay, Jonathan P. Beauchamp, Mark Alan Fontana, Peter Eibich, Martin Kroh ...
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Genetic Variants Linked to Education Predict Longevity

Educational attainment is associated with many health outcomes, including longevity. It is also known to be substantially heritable. Here, we used data from three large genetic epidemiology cohort studies (Generation Scotland, n = ∼17,000; UK Biobank, n = ∼115,000; and the Estonian Biobank, n = ∼6,000) to test whether education-linked genetic variants can predict lifespan length. We did so by using ...

In: Proceedings of the National Academy of Sciences of the United States of America 113 (2016), 47, S. 13366-13371 | Riccardo E. Marioni, Stuart J. Ritchie, Peter K. Joshi, Peter Eibich, Martin Kroh ...
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Genome-Wide Analysis Identifies 12 Loci Influencing Human Reproductive Behavior

The genetic architecture of human reproductive behavior—age at first birth (AFB) and number of children ever born (NEB)—has a strong relationship with fitness, human development, infertility and risk of neuropsychiatric disorders. However, very few genetic loci have been identified, and the underlying mechanisms of AFB and NEB are poorly understood. We report a large genome-wide association study of ...

In: Nature Genetics 48 (2016), 12, S. 1462-1472 | Nicola Barban, Rick Jansen, Ronald de Vlaming, Gert G. Wagner ...
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Genetic Variants Associated with Subjective Well-Being, Depressive Symptoms, and Neuroticism Identified through Genome-Wide Analyses

Very few genetic variants have been associated with depression and neuroticism, likely because of limitations on sample size in previous studies. Subjective well-being, a phenotype that is genetically correlated with both of these traits, has not yet been studied with genome-wide data. We conducted genome-wide association studies of three phenotypes: subjective well-being (n = 298,420), depressive ...

In: Nature Genetics 48 (2016), 6, S. 624-632 | Aysu Okbay, Bart M. L. Baselmans, Jan-Emmanuel De Neve, Peter Eibich, Gert G. Wagner ...
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Exercise at Different Ages and Appendicular Lean Mass and Strength in Later Life: Results from the Berlin Aging Study II

Background. Excessive loss of muscle mass in advanced age is a major risk factor for decreased physical ability and falls. Physical activity and exercise training are typically recommended to maintain muscle mass and prevent weakness. How exercise in different stages of life relates to muscle mass, grip strength, and risk for weakness in later life is not well understood.Methods. Baseline data on 891 ...

In: The Journals of Gerontology : Series A, Medical Sciences 71 (2016), 4, S. 515-520 | Peter Eibich, Nikolaus Buchmann, Martin Kroh, Gert G. Wagner, Elisabeth Steinhagen-Thiessen, Ilja Demuth, Kristina Norman
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Associations between Neighborhood Characteristics, Well-Being and Health Vary over the Life Course

Background: Neighborhood characteristics are important determinants of individual health and well-being. For example, characteristics such as noise and pollution affect health directly, while other characteristics affect health and well-being by either providing resources (e.g. social capital in the neighborhood), which individuals can use to cope with health problems, or limiting the use thereof (e.g. ...

In: Gerontology : International Journal of Experimental, Clinical, Behavioural, Regenerative and Technological Gerontology 62 (2016), 3, S. 362-370 | Peter Eibich, Christian Krekel, Ilja Demuth, Gert G. Wagner
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