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Mental Health Outcomes of Adults Born Very Preterm or with Very Low Birth Weight: A Systematic Review

Aufsätze referiert extern - Web of Science

Rachel Robinson, Marius Lahti-Pulkkinen, Daniel D. Schnitzlein, Falk Voit, Polina Girchenko, Dieter Wolke, Sakari Lemola, Eero Kajantie, Kati Heinonen, Katri Räikkönen

In: Seminars in Fetal & Neonatal Medicine 25 (2020), 3, 101113, 15 S.


Preterm birth research is poised to explore the mental health of adults born very preterm(VP; <32+0 weeks gestational age) and/or very low birth weight(VLBW; <1500g) through individual participant data meta-analyses, but first the previous evidence needs to be understood. We systematically reviewed and assessed the quality of the evidence from VP/VLBW studies with mental health symptoms or disorders appearing in adulthood, excluding childhood onset disorders. Participants (≥18 years, born >1970) included VP/VLBW individuals with controls born at term(≥37+0 weeks) or with normal birth weight(NBW; ≥2500g). Thirteen studies were included. Studies consistently showed an increased risk for psychotropic medication use for VP/VLBW adults in comparison to NBW/term controls, but whether VP/VLBW adults have an increased risk for mental health disorders or symptoms appearing in adulthood remains uncertain. The quality of the evidence was moderate (65.8%) to high (34.2%). Further research in larger samples is needed.

Topics: Health

Keywords: European Union, Horizon 2020, RECAP, PremLife, Preterm, Premature, Very low birth weight, VLBW, Review, Mental disorder, Psychiatric disorder, Depression, Anxiety, Bipolar, Eating disorder, Schizophrenia, Externalizing, Internalizing, Psychiatric diagnosis