Over the last decade, there has been a growing interest in the association between 2D:4D, a putative marker for prenatal testosterone exposure, and economic preferences. The results are mixed, and part of the inconclusiveness may come from the typically limited sample sizes as well as the many “researcher degrees of freedom” in the analysis. To firmly test if 2D:4D is associated with economic preferences much larger studies with pre-registered analysis plans are needed. In this study, we will perform the largest study to date on 2D:4D and economic preferences, on a sample of 4500 individuals, representative of Germany’s adult population. We will test if 2D:4D is associated with risk taking, altruism, positive reciprocity, negative reciprocity and trust. The data will be collected via the 2018 wave of the German Socioeconomic Panel-Innovation Sample (SOEP-IS).